Great post. I've always been interested in this: "Tolerance builds extremely quickly and (given the way cannabinoids are stored in our fat cells) takes a long time to dissipate relative to, say, coffee. [...] leading to reduced dopamine receptor activity for a period after use, particularly the following day or two (normalisation occurs logarithmically, with reduced activity observed for years after use for previously heavy users)." I've noticed tolerance builds quickly, do you have any citations for that? Do you have any citations for logarithmic normalization?
Thanks. It's unfortunate that I didn't link my sources in these early days, and I can't find the exact studies I was referring to. While my statements above still align with my observations, having gone over some of the literature again these past few days, it'd be fair to say the topic is more contentious than I'd realised, especially given the difficulties of measurement (usually via proxies such as impairment), various confounders, etc. See:
I have found the issue not so much contentious as simply understudied. I could find nothing about this topic, for instance, in the HHS' long report recommending rescheduling.
Mmmm. Understudied is a more accurate description. I just note that what studies there are rarely agree on issues like interpretation of results, in part for the reasons I discuss in my OP.
Fascinating post very interesting to ponder. Are you aware if there's any reference in the scientific literature evaluating the idea that cannabis use can be modeled as reduction of the peripheral?
Afraid not. Most studies I've looked at are along the lines I discuss I above, but pharmacology is admittedly not my area of expertise. I'd be interested in hearing what you come across.
Great post. I've always been interested in this: "Tolerance builds extremely quickly and (given the way cannabinoids are stored in our fat cells) takes a long time to dissipate relative to, say, coffee. [...] leading to reduced dopamine receptor activity for a period after use, particularly the following day or two (normalisation occurs logarithmically, with reduced activity observed for years after use for previously heavy users)." I've noticed tolerance builds quickly, do you have any citations for that? Do you have any citations for logarithmic normalization?
Thanks. It's unfortunate that I didn't link my sources in these early days, and I can't find the exact studies I was referring to. While my statements above still align with my observations, having gone over some of the literature again these past few days, it'd be fair to say the topic is more contentious than I'd realised, especially given the difficulties of measurement (usually via proxies such as impairment), various confounders, etc. See:
https://www.jsad.com/doi/pdf/10.15288/jsad.2016.77.992?role=tab
I have found the issue not so much contentious as simply understudied. I could find nothing about this topic, for instance, in the HHS' long report recommending rescheduling.
Mmmm. Understudied is a more accurate description. I just note that what studies there are rarely agree on issues like interpretation of results, in part for the reasons I discuss in my OP.
Fascinating post very interesting to ponder. Are you aware if there's any reference in the scientific literature evaluating the idea that cannabis use can be modeled as reduction of the peripheral?
Afraid not. Most studies I've looked at are along the lines I discuss I above, but pharmacology is admittedly not my area of expertise. I'd be interested in hearing what you come across.